233 papers
The study demonstrates that Personal-MetaboHealth, a personalized and clinically validated metabolomic score derived from a Dutch reference population, robustly predicts all-cause mortality and cardiometabolic disease onset in middle-aged individuals and can be effectively improved through a targeted lifestyle intervention for those at risk.
This qualitative study of racially and ethnically minoritised groups in South East London reveals that while informal support networks are vital for navigating community safety and mental well-being amidst institutional distrust and structural inequality, they cannot replace the need for adequately resourced, culturally informed public provisions.
This qualitative study in Karachi demonstrates that a participatory storytelling intervention significantly enhances individual empowerment and reduces self-stigma among persons affected by leprosy by fostering self-acceptance and peer solidarity, though its broader societal impact remains constrained by persistent community misconceptions, gender norms, and structural barriers.
This study in rural Kenya demonstrates that while cash incentives and revisits significantly increase participation in door-to-door COVID-19 testing and help reduce nonresponse bias, offering a lower incentive of KSh 200 proved more cost-effective than higher amounts despite slightly lower detection rates among the hardest-to-reach individuals.
This study utilized LASSO-regression analysis on 207 long-distance truck drivers along the Kenya-Uganda corridor to reveal a 51.7% prevalence of occupational fatigue, identifying deadline pressure, stimulant use, and excessive shift lengths as key predictors that necessitate urgent regulatory and organizational interventions.
This study utilizes long-read metagenomics and methylation-based binning to overcome sequencing limitations, successfully identifying previously unreported antibiotic resistance genes and their diverse environmental hosts in wastewater, thereby highlighting the critical role of non-pathogenic bacteria as intermediate carriers in the emergence and dissemination of high-risk resistance threats.
This descriptive analysis of 17 free physical activity apps reveals that while they are generally well-rated and frequently employ basic behavior change techniques like goal setting and feedback, they often lack comprehensive evidence-based strategies, suggesting a need for developers to incorporate more robust behavior change methods to better improve user health outcomes.
This cross-sectional study of 563 Indonesian high school students reveals that high cotinine levels, indicating significant nicotine exposure and chronic disease risk, are primarily driven by daily cigarette consumption, male gender, having smoking family members, and low physical activity, though these factors did not significantly correlate with a willingness to join smoking cessation programs.
This multi-country cohort analysis in Nigeria, Cameroon, and South Africa demonstrates that while Hepatitis C self-testing effectively identifies infected individuals, including those with severe disease, treatment uptake and retention vary significantly across settings, with South Africa showing notably lower engagement rates driven by HIV status compared to higher success in Cameroon and Nigeria, highlighting the urgent need to strengthen decentralized care pathways to ensure treatment access.
This manuscript, which investigated the association between Life's Crucial 9 and chronic kidney disease risk using NHANES 2005–2018 data, has been withdrawn by medRxiv because it was published without the full consent of all authors.
The Global Pathogen Analysis System (GPAS) is an accessible online AI platform that combines a novel hybrid machine learning framework for rapid, high-accuracy pathogen identification with a specialized large language model agent to autonomously generate clinically actionable, evidence-based interpretations of complex metagenomic data.
This study quantifies the substantial and growing economic burden of measles in the United States, demonstrating that even marginal annual declines in MMR vaccination coverage can trigger a nonlinear surge in cases, hospitalizations, and costs, potentially reaching $7.77 billion over five years.
This paper analyzes a global panel of disease-specific publications and burdens from 1990 to 2021 to demonstrate that while research systems increasingly reallocate effort toward endemic health needs and respond rapidly to outbreak alerts, this responsiveness remains uneven across regions and is disproportionately driven by philanthropic and government funding in lower-income settings.
The Legionella International Typing (LIT) workgroup developed and validated a high-resolution cg/wgMLST schema based on 9000 genomes to enhance the discriminatory power and harmonization of *Legionella pneumophila* genomic surveillance for outbreak detection and source identification.
This manuscript, titled "The impact of tobacco control policies on illicit tobacco trade: A scoping review," has been withdrawn by the authors to work on a substantially revised version and should not be cited.
This quantitative microbial risk assessment study concludes that while pasteurization effectively eliminates the risk of human H5N1 infection from cow's milk, raw milk consumption poses a measurable risk that can be mitigated through bulk tank testing, though further research is needed on dose-response dynamics and consumption patterns.
This multi-country study of over 3,000 adults in Botswana, Ghana, Nigeria, and Tanzania reveals that higher COVID-19 symptom burdens and chronic disease loads are significantly associated with poorer executive function, with notable cross-country variations and education emerging as a consistent protective factor.
This study compares three rule-based algorithms designed to retrieve pregnancy-related adverse event reports from pharmacovigilance databases, revealing that differences in their flagged reports stem primarily from varying scopes regarding age restrictions, normal pregnancies, and paternal exposure, thereby highlighting the need for professionals to select the most appropriate tool based on their specific research needs.
This study demonstrates that routine daily dietary choices, specifically higher fiber density, greater plant diversity, and heavier evening meals, have immediate and measurable effects on objective sleep architecture and nocturnal heart rate, whereas short-term variations in macronutrient distribution and micronutrient intake show no robust associations.
This paper argues that current age-based adult vaccine policies in Europe exacerbate health inequalities by excluding vulnerable populations with shorter life expectancies, and proposes adopting place-based eligibility models that account for local deprivation to ensure earlier access for those most in need.